Thihathu was a co-founder of the Myinsaing Kingdom, and the founder of the Pinya Kingdom in today's central Burma (Myanmar). Thihathu was the youngest and most ambitious of the three brothers that successfully defended central Burma from Mongol invasions in 1287 and in 1300–01. He and his brothers toppled the regime at Pagan in 1297, and co-ruled central Burma. After his eldest brother Athinkhaya's death in 1310, Thihathu pushed aside the middle brother Yazathingyan, and took over as the sole ruler of central Burma. His decision to designate his adopted son Uzana I heir-apparent caused his eldest biological son, Saw Yun to set up a rival power center in Sagaing in 1315. Although Saw Yun nominally remained loyal to his father, after Thihathu's death in 1325, the two houses of Myinsaing officially became rival kingdoms in central Burma.
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